ADULT-ONSET ACNE: MOLECULAR GENETIC ANALYSIS

Номер журнала:

Год издания:

2011

O.N. Karymov1,3; L.I. Kutuyeva2, V.V. Ashapkin2, Cand. Biol. Sci.; Professor S.B. Tkachenko, MD, Corresp. Member of the Russian Academy of Medical Sciences; Professor N.N. Potekayev, MD
1Laboratory for Study of Skin Reparative Processes, Research Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University; 2A.N. Belozersky Research Institute of Physicochemical Biology, M.V. Lomonosov Moscow State University; 3Dermatovenereological Dispensary Nineteen, Moscow

The authors have made a critical analysis of data on the molecular genetic mechanisms of occurrence of late forms of acne. They have analyzed the nature of signaling and metabolic pathways the impairments of which lead to the occurrence of pathological processes characteristic of acne, its late forms in particular. A possible role of different elements of the androgen system in the emergence of acne and their association with the gene regulatory systems of lipid metabolism in the skin cells are discussed.

Key words: late forms of acne

androgens

sebocytes

lipid metabolism

genes