Problems in the development of immunoresistance to botulinum toxin in aesthetic practice

The paper considers the secondary and primary immunoresistance to botulinum toxin preparations. It identifies the patient selection criteria that reduce the risk of immunoresistance when botulinum toxin preparations are regularly used in aesthetic practice. The approach to correcting mimic wrinkles is proposed to be changed in some patient groups in order to reduce the number of negative and relatively negative results.